Ankylosing Spondylitis

Ankylosing Spondylitis (AS) is a chronic inflammatory condition primarily affecting the spine and sacroiliac joints, leading to progressive stiffness and pain. Over time, the inflammation can cause the vertebrae to fuse, significantly limiting mobility. This condition is more common in young adults, particularly men, and is closely associated with the HLA-B27 genetic marker. Symptoms often begin with lower back pain and stiffness, which worsens with inactivity and improves with movement. In some cases, AS may also affect other joints, eyes (uveitis), and even the cardiovascular system.

Dr. Naval Mendiratta emphasizes the importance of early diagnosis and treatment to prevent irreversible damage. Management strategies include nonsteroidal anti-inflammatory drugs (NSAIDs), physical therapy, and biological therapies like TNF inhibitors to control inflammation. Lifestyle modifications, including regular exercise and maintaining good posture, can help improve quality of life. In severe cases, surgical intervention may be necessary. Since AS is a lifelong condition, continuous monitoring, and personalized treatment plans are crucial to managing symptoms effectively.